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Written by two highly respected and influential developmental biologists lewis wolpert and cheryll tickle principles of development fourth edition combines a careful exposition of the subject with insights from several of the worlds pioneering researchers. Lewis wolpert cbe frs frsl fmedsci born 19 october 1929 is a south african born british developmental biologist author and broadcaster wolpert is recognized for his work on the intracellular positional information that guides cellular development in addition he has published several popular science books bron wikipedia. Buy principles of development on amazoncom free shipping on qualified orders principles of development wolpert lewis tickle cheryll martinez arias alfonso 9780198800569 amazoncom books skip to main content. Principles of development 4th edition wolpert pdf free download mirror 1. Principles of development clearly illustrates the universal principles that govern this process of development in a succinct and accessible style written by two highly respected and influential developmental biologists lewis wolpert and cheryll tickle it focuses on those systems that best illuminate the common principles covered in the text and avoids overwhelming the reader with
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Lewis Wolpert, Rosa Beddington, Thomas Jessell, Peter Lawrence, Elliot Meyerowitz, Jim Smith
Principles of Development, Second Edition
2002
Oxford University Press
ISBN 0-19-924939-3
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Lewis Wolpert, Rosa Beddington, Thomas Jessell, Peter Lawrence, Elliot Meyerowitz, Jim Smith Principles of Development, Second Edition 2002 Oxford University Press ISBN 0-19-924939-3. Preface; Contents. Developmental biology is at the core of all biology. Trove is unable to load.
Developmental biology is at the core of all biology. It deals with the process by which the genes in the fertilized egg control cell behavior in the embryo and so determine its pattern, its form, and much of its behavior. The progress in developmental biology in recent years with the application of advances in cell and molecular biology has been remarkable, and an enormous amount of information is now available.
In this second edition, we have included many recent advances, for example in the understanding of somite formation, and this new material is complemented by over 30 additional illustrations. Sections on the development of the heart, the vascular system, and teeth have been added, and we have given more attention, for example, to stem cells, signal transduction, and evolution.
Principles of Development is designed for undergraduates and the emphasis is on principles and key concepts. Central to our approach is that development can be best understood by understanding how genes control cell behavior. We have assumed that the students have some very basic familiarity with cell biology and genetics, but all key concepts, such as the control of gene activity, are explained in the text.
Conscious of the pressures on students, we have tried to make the principles as clear as possible and to provide numerous summaries, in both words and pictures. The illustrations in this book are a special feature and have been carefully designed and chosen to illuminate both experiments and mechanisms.
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We have resisted the temptation to cover every aspect of development and have, instead, focused on those systems that best illuminate common principles. Indeed, a theme that runs throughout the book is that universal principles govern the process of development. At all stages, what we included has been guided by what we believe undergraduates should know about development.
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We have thus concentrated our attention on vertebrates and Drosophila, but not to the exclusion of other systems, such as the nematode and the sea urchin, where they best illustrate a concept. An important feature of our book is the inclusion of the development of plants, which is usually neglected in textbooks. There have been striking advances in plant developmental biology in recent times, and some unique and important features have emerged. As knowing the basic features of the embryology of the main organisms used to study development is essential for an understanding of molecular mechanisms, we have introduced embryology at an early stage.
Whereas our emphasis has been on the laying down of the body plans and organ systems, such as limbs and the nervous system, we have also included later aspects of development, including growth and regeneration. The book concludes with a consideration of evolution and development.
In providing references, our prime concern has been to guide the students to helpful papers rather than to give credit to all the scientists who have made major contributions: to those whom we have neglected, we apologize.
For this new edition we welcome Jim Smith as a co-author and say goodbye to Jeremy Brockes, with thanks for all his help. Each chapter has also been reviewed by a number of experts (see page xix), to whom we give thanks. As with the first edition, I did all the writing-and I mean writingin consultation with my co-authors; it was typed by Maureen Maloney and my revisions were deciphered, edited, and incorporated by our editor Eleanor Lawrence, whose expertise and influence pervades the book. Most of the new illustrations were brilliantly created or adapted by Matthew McClements, who created the illustrations for the first edition.
We are indebted to Jonathan Crowe, John Grandidge, and the illustrators at Oxford University Press, our new publishers, for their help and patience throughout the preparation of this new edition. My thanks to Vitek Tracz and Peter Newmark of the Current Science Group, without whom the first edition of this book would never have been started, let alone completed.
Finally, and sadly, we are acutely conscious of the loss of Rosa Beddington, who died last year, after a long illness. She was helpful to the end and we miss her terribly.
L. W.
London
September 2001
London
September 2001
- List of headings
- Text acknowledgments
- Figure acknowledgments
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- Chapter 1: History and basic concepts
- The origins of developmental biology
- A conceptual tool kit
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- Chapter 2: Model systems
- Model organisms: vertebrates
- Model organisms: invertebrates
- Model systems: plants
- Identifying developmental genes
- Chapter 3: Patterning the vertebrate body plan I: axes and germ layers
- Setting up the body axes
- The origin and specification of the germ layers
- Chapter 4: Patterning the vertebrate body plan II: the mesoderm and early nervous system
- Somite formation and patterning
- Neural induction and the role of the organizer
- Chapter 5: Development of the Drosophila body plan
- Maternal genes set up the body axes
- Polarization of the body axes during oogenesis
- Zygotic genes pattern the early embryo
- Segmentation: activation of the pair-rule genes
- Segment polarity genes and compartments
- Segmentation: selector and homeotic genes
- Chapter 6: Development of nematodes, sea urchins, ascidians, and slime molds
- Nematodes
- Echinoderms
- Ascidians
- Cellular slime molds
- Chapter 7: Plant development
- Embryonic development
- Meristems
- Flower development
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Principles Of Development 5th Edition Lewis Woolpert Free Pdf Online
- Chapter 8: Morphogenesis: change in form in the early embryo
- Cell adhesion
- Cleavage and formation of the blastula
- Gastrulation
- Neural tube formation
- Cell migration
- Directed dilation
- Chapter 9: Cell differentiation
- The control of gene expression
- Models of cell differentiation
- The reversibility of patterns of gene activity
Principles Of Development 5th Edition Lewis Wolpert Free Pdf Download
- Chapter 10: Organogenesis
- The chick limb
- Insect wings and legs
- The nematode vulva
- Internal organs: heart, blood vessels, lungs, kidneys, and teeth
- Chapter 11: Development of the nervous system
- Specification of cell identity in the nervous system
- The insect compound eye
- Axonal guidance
- Neuronal survival, synapse formation, and refinement
- Chapter 12: Germ cells and sex
- Determination of the sexual phenotype
- The development of germ cells
- Fertilization
- Chapter 13: Regeneration
- Limb regeneration
- Regeneration in Hydra
- Chapter 14: Growth and post-embryonic development
- Growth
- Molting and metamorphosis
- Aging and senescence
- Chapter 15: Evolution and development
- Modification of development in evolution
- Changes in the timing of developmental processes during evolution
- Evolution off development
- Glossary
- Index